Interim Analysis and Sample Size Reassessment
The procedure without early acceptance is described in detail in SampleSize.pdf.
The following Mathematica notebooks are available for download:
General Computations for Sample Size Reassessment: Reassess.nb
Sample Size Minimization:
For the procedure
without early acceptance (Minimize over n1): Minimize_n1.nb,
with early acceptance (Minimize over alpha1): Minimize_a1.nb.
For questions please contact Martin Posch.